Mantis
Mantis is a YC Winter 2026 (W26) company. Based in New York City, NY, USA. Team of 3.
About Mantis
Summary
Mantis builds behavioral forecasting infrastructure by combining large language models with physics-based simulations to construct digital twins of individual people. The models ingest continuous physiological and behavioral data, such as smartwatch readings and digital interactions, to produce predictive forecasts of a person's physiology and behavior over clinically relevant time horizons. The company is starting in medicine, where its twins replace manual, intuition-driven patient assessment with model-driven trajectory forecasts.
Go-to-market
Mantis sells to medical and healthcare buyers, with the digital twin serving as infrastructure that clinicians or health systems plug into existing decision workflows.
From the Y Combinator listing
Digital Twins of humans
Mantis is a digital twin company that combines LLMs with high-fidelity physics simulations in order to convert rare and difficult-to-access human behavior data into predictive models.
Facts
- B2B / B2B -> Infrastructure
- New York City, NY, USA
- 3
- Active
- Early
Founders (1)
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